PREVALENCE AND ASSOCIATED FACTORS OF ORAL NON-CANDIDA ALBICANS CANDIDA CARRIAGE IN DENTURE WEARERS IN SANA'A CITY- YEMEN

Khaled Abdulsalam Al-Haddad; Omar Ahmed Esma’il Al-dossary; Hassan A. Al-Shamahy

doi:10.22270/ujpr.v3i4.176

Khaled Abdulsalam Al-Haddad Department of Orthodontic Pediatric Dentistry, Faculty of Dentistry, Sana’a University, Sana’a, Yemen
Omar Ahmed Esma’il Al-dossary Medical Microbiology Clinical Immunology, Faculty of Medicine Health Sciences, Sana’a University, Republic of Yemen
Hassan A. Al-Shamahy 3Faculty of Medicine Heath Sciences, Sana'a University, P.O. Box 775 Sana'a, Yemen

10.22270/ujpr.v3i4.176

Keywords:

carriage, denture, Non-Candida albicans andida (NCAC), prevalence

Abstract

Objective: The objective of this study was to contrast the prevalence and species of colonization of Non-Candida albicans (NCAC) in the oral cavity of denture wearers and non-denture wearers; also asses associated risk factors of their colonization.

Methods: A total of 208 subjects were studied: 104 denture wearers and 104 non-denture wearers, matched by age, sex, comprised the experimental control groups, respectively. Each subject was instructed to perform oral rinsing using a phosphate-buffered saline solution, which was expectorated processed for the recovery of Candida species on on Sabouraud dextrose agar. Isolates were identified by culturing on chromogenic Candida agar noting species-specific colony characteristics.

Results: There was a significant oral carriage rate of NCAC among denture wearers (5.83% versus 11.1% in controls) with associated risk factor (5.4) (PV<0.001). The most common isolated NCAC were C. Krusi C. tropicalis with significant OR (5.5 4.7 respectively). When co-infections were considered, there was highly significant association of C. albicans + C. krusi oral colonization in cases (OR=4.56, PV<0.001). There was a significant oral carriage rate of NCAC among male denture wearers (36.9%, OR=6.6, PV˂0.001). In addition, there was a significant rate of NCAC colonization with complete denture (rate= 50%, OR=2.4, PV= 0.02). While no significant increase associated with colonization of NCAC with partial, acrylic /or chrome cobalt denture.

Conclusion: Based on the results of this study ability of NCAC were greater in denture wearers than non-denture wearers, also greater risk of NCAC were found with males, older ages, complete denture.