FORMULATION AND EVALUATION OF FINASTERIDE SUSTAINED-RELEASE MATRIX TABLETS USING DIFFERENT RATE CONTROLLING POLYMERS

  • Igwe J. Chibueze Department of Pharmaceutical Microbiology and biotechnology, Gombe state University, Nigeria
  • Emenike IV Department of Pharmaceutical Microbiology and biotechnology, Gombe state University, Nigeria
  • Oduola A R Department of Pharmaceutical Microbiology and biotechnology, Gombe state University, Nigeria
10.22270/ujpr.v1i2.R3

Keywords:

Sustained release, matrix tablets, wet granulation

Abstract

Objective: Finasteride is chemically considered a synthetic 4-azasteroid drug used in the treatment of anti-hyperplasia. In matrix system of sustained release drug is dispersed homogenously throughout a polymeric matrix. The aim of the present investigation was to develop oral controlled release matrix tablet formulations of Finasteride with different polymer ratios.

Methods: The granules were evaluated for angle of repose, bulk density and Compressibility index before being punched as tablets. Total 5 varieties o of tablets were compressed using polymers (HPMC, EC, Eudragit RS100) in different ratio. The tablets were subjected to weight variation test, drug content, hardness, friability, and in vitro release studies. Different models for kinetic study were applied like zero order, first order, Higuchi, Hixson Crowell and Korsmeyer to study the release pattern and mechanism.

Results: All the formulations showed uniform thickness. In a weight variation test, the pharmacopoeial limit for percentage deviation for the tablets of more than 250 mg is ±5%. The formulation MT5 showed a comparatively high hardness value of 4.8±0.22 kg/cm2. Matrix tablets of batch MT1 shows maximum release 86.42% in 10 hrs.

Conclusion: Observations of all formulations for physical characterization had shown that, all of them comply with the specifications of official pharmacopoeias and/or standard references. Study concludes that Finasteride can be delivered effectively in the form of matrix tablets.

31.JPG

Peer Review History:

Article received on- 8 October 2016;  Revised on- 11 November; Accepted on- 14 December;  Available online 15 January 2017

Academic Editor: Ahmad Najiborcid22.jpg, Universitas Muslim Indonesia,  Indonesia, ahmad.najib@umi.ac.id

Received file:blue_23983.gif        Reviewer's Comments:download_logo_r_29189.gif

Average Peer review marks at initial stage: 4.0/10

Average Peer review marks at publication stage: 7.0/10

Reviewer(s) detail:

Dr. Barkat Ali Khanorcid22.jpg, Kampala International University , Uganda, barki.gold@gmail.com

Dr. Dalia Kamal Zaffar Aliorcid22.jpg, Modern University for technology and information, Egypt, dr.moda88@gmail.com

Downloads

Crossmark
Statistics
740 Views | 455 Downloads
Dimension Citations

Published

2016-11-01

How to Cite

Chibueze, I. J., E. IV, and O. A. R. “FORMULATION AND EVALUATION OF FINASTERIDE SUSTAINED-RELEASE MATRIX TABLETS USING DIFFERENT RATE CONTROLLING POLYMERS”. Universal Journal of Pharmaceutical Research, vol. 1, no. 2, Nov. 2016, doi:10.22270/ujpr.v1i2.R3.

Issue

Section

Research Articles
Share |

Similar Articles

You may also start an advanced similarity search for this article.