IN -VIVO ANTI-DIARRHOEAL ACTIVITY OF METHANOL EXTRACT OF BOMBAX BUONOPOZENSE

Abstract

Objective: Diarrhoeal disease is responsible for mortality and morbidity, especially among children in developing countries causing a major healthcare problem. The purpose of the present study was to evaluate anti-diarrhoeal effects of methanolic extract of whole plant of Bombax buonopozense against castor oil-induced-diarrhoea model and small intestine transit model in rats. 

Methods: Albino wistar rats were used for estimation of anti-diarrhoeal activity. Small intestinal transit models in rats the number of droppings and the distance traveled by charcoal in intestine were measured.  Loperamide (2.5 mg/kg) was used as standard drug, and it has shown significant reductions in fecal output and frequency of droppings whereas extract at the doses of 200 and 400 mg/kg reduced the castor-oil induced frequency and consistency of diarrhoea. 

Results: The results obtained establish the efficacy and substantiate the folklore claim as an anti- diarrhoeal agent.

Conclusion: Results conclude that the leaves extract of Bombax buonopozense contains bioactive natural substances with antidiarrhoeal properties.

Peer Review History:

Received 8 December 2016;   Revised 7 January 2017; Accepted 11 February, Available online 15 March 2017

Academic Editor: 

Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com

Received file:        Reviewer's Comments:

Average Peer review marks at initial stage: 3.5/10

Average Peer review marks at publication stage: 7.0/10

Reviewer(s) detail:

Dr. Gülay B Anadolu, Anadolu University, Eskisehir, Turkey, gbuyukko@anadolu.edu.tr

 Prof. Dr. Hüsniye Kayalar, Ege University, Turkey, husniyekayalar@gmail.com