PREPARATION AND CHARACTERIZATION OF TOLTERODINE TARTRATE PRONIOSOMES

  • Adim Ekene Ugochukwu Department of Biochemistry, Ahmadu Bello University Zaria, Nigeria
  • Obeta Judith Nnedimkpa University of Nigeria Nsukka, Nigeria
  • Ngwu Ogochukwu Rita Caritas University Enugu, Nigeria
10.22270/ujpr.v2i2.R1

Keywords:

Tolterodine tartrate, proniosome, Span 60, Tween 40, in vitro release

Abstract

Objective: Proniosomes are dry free flowing, granular products that are water soluble carrier particles, coated with surfactants and can be hydrated to form niosomal dispersion immediately before use in hot aqueous media. Tolterodine, is medication used to treat frequent urination, urinary incontinence, or urinary urgency. It acts on M2 and M3 subtypes of muscarinic receptors.

Methods: Tolterodine tartrate proniosome formulations were prepared by coacervation phase separation method by using different surfactants in different ratios.  The prepared proniosomal formulations were evaluated for vesicle size, rate of spontaneity, encapsulation efficiency, drug content, In vitro release study and stability studies.

Results: The size range was found to be 15.28±0.33 to 16.43±0.22 µm. Viscosity of all formulations lies in the range of 7244-9314 cp. Maximum release was shown by formulations of batch PG4 (87.45 %), and minimum for formulations of batch PG4 (50%), after 12 h. Optimized formulations PG4 shows stability at different temperatures.

Conclusion: Tolterodine tartrate proniosome formulations prepared by using coacervation phase separation method are capable of releasing drug for the extended period of time.

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Peer Review History:

Received 9 February 2017;   Revised 7 March; Accepted 26 April, Available online 15 May 2017

Academic Editor: Dr. DANIYAN Oluwatoyin Michaelorcid22.jpg, Obafemi Awolowo University, ILE-IFE, Nigeria, toyinpharm@gmail.com

Received file:blue_23983.gif        Reviewer's Comments:download_logo_r_29189.gif

Average Peer review marks at initial stage: 3.0/10

Average Peer review marks at publication stage: 7.0/10

Reviewer(s) detail:

Dr. Mohammed Abdel-Wahab Sayed Abourehaborcid22.jpg, Umm Al-Qura University; Makkah Al-Mukarramah, Saudi Arabia, mohawahab2002@yahoo.com

Dr. Sally A. El-Zahabyorcid22.jpg, Pharos University in Alexandria, Egypt, sally.elzahaby@yahoo.com

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Published

2017-03-01

How to Cite

Ugochukwu, A. E., O. J. Nnedimkpa, and N. O. Rita. “PREPARATION AND CHARACTERIZATION OF TOLTERODINE TARTRATE PRONIOSOMES”. Universal Journal of Pharmaceutical Research, vol. 2, no. 2, Mar. 2017, doi:10.22270/ujpr.v2i2.R1.

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