ANTIHYPERLIPIDEMIC EFFECT OF THE ETHANOLIC EXTRACT OF SCAEVOLA TACCADA (GAERTN) ROXB. LEAVES

Rahma Wati; Irma Santi; Julfa Jafar; Adinda Putri Sangaji; Aulia Wati

doi:10.22270/ujpr.v5i5.486

Rahma Wati Department of Pharmacology and Biopharmaceutical, Faculty of Pharmacy-University of Muslim Indonesia Makassar, Indonesia.
Irma Santi Department of Pharmacology and Biopharmaceutical, Faculty of Pharmacy-University of Muslim Indonesia Makassar, Indonesia.
Julfa Jafar Department of Pharmacology and Biopharmaceutical, Faculty of Pharmacy-University of Muslim Indonesia Makassar, Indonesia.
Adinda Putri Sangaji Department of Pharmacology and Biopharmaceutical, Faculty of Pharmacy-University of Muslim Indonesia Makassar, Indonesia.
Aulia Wati Department of Pharmacology and Biopharmaceutical, Faculty of Pharmacy-University of Muslim Indonesia Makassar, Indonesia.

10.22270/ujpr.v5i5.486

Keywords:

Antihyperlipidemia, ethanolic extract, Scaevola taccada (Gaertn.) Roxb

Abstract

Objective: The research aimed to determine the effect of ethanolic extract of Scaevola taccada (Gaertn.) Roxb leaves in hyperlipidemic rats WITH Cholesterol and triglyceride parameter.

Methods: The research used 30 samples divided into 6 groups: group I (negative control) was given Sodium Carboxymethyl cellulose of 1% w/v , group II (positive control) was given simvastatin of 1.023 mg/kg Body weight, Group III was given gemfibrozil 167.60kg/Body Weight, group IV, V and VI were respectively given ethanolic extract of Scaevola taccada (Gaertn) Roxb with the doses of 700 mg/kg body weight 900 mg/kg body weight, and 1100 mg/kg body weight. The sample was fed a high-fat diet during treatment and induced pure cholesterol for 28 days, the provision of dosage form was done orally once a day for 14 days and the measurement of rat cholesterol and triglycerides, level was done on day 0, 29, and 43. The research data were processed statistically by one way ANOVA test followed by Post Hoc Bonferroni test.

Results: The result showed that the positive control group had no significant effect compared on ethanol extract Scaevola taccada (Gaertn.) Roxb. group (p> 0,5).

Conclusion: The conclusion is the ethanolic extract of Scaevola taccada (Gaertn.) Roxb. leaves had an activity in reducing cholesterol and triglyceride level in rat hyperlipidemia and with an effective dose of 1100 mg /kg body weight.