EVALUATION OF METHANOLIC EXTRACT OF EUPHORBIA NERIIFOLIA STEM BARK ON BLOOD SUGAR LEVELS, SERUM AND TISSUE LIPIDS IN A PRECLINICAL MODEL

Abstract

Objective: The present study is undertaken to evaluate the effect of Euphorbia neriifolia stem bark on blood glucose and lipid levels in experimental diabetic rats.

Methods: Methanolic extract of Euphorbia neriifolia stem bark (MEEN) was administered at different doses and its effect on blood glucose, haemoglobin, serum and tissue lipids, hexokinase and glucose-6-phosphatase in streptozotocin-induced diabetic rats were studied. Glibenclamide was used as standard reference drug.

Results: Euphorbia neriifolia methanolic extract (MEEN), at doses of 100,200 and 400mg/kg body weight for 30 days, suppressed the elevated blood glucose and lipid levels in diabetic rats. Euphorbia neriifolia at 400mg/kg was found to be comparable to glibenclamide.

Conclusion: The study indicates that the Euphorbia neriifolia possess antihyperlipidaemic effect as well as antidiabetic activity.

                               

Peer Review History:

Received 13 April 2017;   Revised 5 May; Accepted 27 June, Available online 15 July 2017

Academic Editor: Dr. Asia Selman Abdullah, Al-Razi university, Department of Pharmacy, Yemen, asia_abdullah65@yahoo.com

Received file:        Reviewer's Comments:

Average Peer review marks at initial stage: 5.0/10

Average Peer review marks at publication stage: 7.5/10

Reviewer(s) detail:

Dr. Mohamed Derbali, Faculty of Pharmacy, Monastir, Tunisia, mohamed.edderbali@gmail.com

Dr. Sabah Hussien El-Ghaiesh, Tanta University, Egypt, s.ghaiesh@gmail.com