REPRODUCTIVE HORMONE LEVELS AND METABOLIC SYNDROME IN WOMEN WITH POLYCYSTIC OVARY SYNDROME IN SANA'A, YEMEN

Libia Sina; Alariqi Reem; Wadee Abdullah Al-Shehari; Wadhah Hassan Edrees; Raba’a Mohammed Jumaan; Samar Naji Abdullah Abdulaziz Al-Tamimi

doi:10.22270/ujpr.v6i4.640

Libia Sina Department of Microbiology, Faculty of medicine and health sciences, Sana’a University, Yemen.
Alariqi Reem Department of Microbiology, Harbin Medical University, 157 Baojian Road, Harbin 150081, China.
Wadee Abdullah Al-Shehari Department of Microbiology, Harbin Medical University, 157 Baojian Road, Harbin 150081, China. Department of Microbiology, Faculty of Medical Sciences, Ibb University, Yemen.
Wadhah Hassan Edrees Medical Laboratory Department, College of Medical Sciences, Al-Razi University, Yemen.Medical Microbiology Department, Faculty of Applied Sciences, Hajjah University, Yemen.
Raba’a Mohammed Jumaan Department of Microbiology, Faculty of medicine and health sciences, Sana’a University, Yemen.
Samar Naji Abdullah Abdulaziz Al-Tamimi Department of General medicine and surgery, Faculty of medicine and Healthy sciences, Taiz University, Yemen.

10.22270/ujpr.v6i4.640

Keywords:

Hormones, insulin, metabolic risk factors, polycystic ovary syndrome

Abstract

Background and Objectives: Polycystic ovary syndromes (PCOs) are the most complex endocrine disorders of the female reproductive system with metabolic and psychiatric manifestations. It affects 5%-10% of women of childbearing age. There are paucity of information on PCOs. Therefore the present study aimed at the effect of reproductive hormones, metabolic syndromes, smoking and khat chewing on the PCOs among women in Sana'a

Subjects and Methods: The study included 45 Yemeni women of the age group 18-45 years with PCO_S classified into two groups regarding age: Group I 18-29 years old, Group II 30-45 years old and underwent clinical assessment (waist, BMI and sex hormones, blood pressure, glucose, lipids, and insulin), and transvaginal ultrasound. Clinical data, history of other diseases and data of chewing and smoking also collected.” Also the study included 45 healthy control women matched in age with the cases.

Results: The prevalence of MS among PCOs patients was 35% and the most prevalent MS risk factors among PCOs patients were waist circumference (WC) 64.4%, and HDL-C 64.4% respectively, while prevalence of triglycerides (TG), hypertension and fasting blood sugar (FBS) were 28.9%, 20% and 13.3%, respectively. PCOs patients had significant increase in serum levels of luteinizing hormone (LH) (p<0.001), Insulin (p<0.001), HOMA-IR (p<0.001), T testosterone (TT) (p<0.001), DHEA-S (p<0.001) and FBS (p<0.016). Lean PCOs patients had a significant increase in TT than overweight/obese PCOs (p < 0.045) and dehydroepiandrosterone sulfate (DHEA-S) was found to be significantly higher in PCOs women with MS (p<0.011). Insulin resistance was significantly higher in PCOs women with hypertension as compared to PCOs women without hypertension (p<0.023).

Conclusion: There is a relationship between PCO_S and reproductive hormone disorder. Patients had significant increases in serum levels of LH, LH/Follicle Stimulating Hormone (FSH), Insulin, TT, and DHEA-S. Also, a relationship was found between the syndrome and infertility, hirsutism, irregular menstruation, polycystic ovaries and multiple sclerosis.