SILICA IODIDE CATALYZED ULTRASOUND ASSISTED ONE-POT THREE-COMPONENT SYNTHESIS OF 3,4-DIHYDROPYRIMIDINE-2-(1H)-ONES/-THIONES

Amreen Khanum; Riyaz-ur-Rahaman Khan; Mangalavathi M; Mohamed Afzal Pasha

doi:10.22270/ujpr.v6i5.672

Amreen Khanum Department of Chemistry, Jnanabharathi Campus, Bangalore University, Bengaluru-560056, India.
Riyaz-ur-Rahaman Khan Department of Chemistry, Jnanabharathi Campus, Bangalore University, Bengaluru-560056, India.
Mangalavathi M Department of Chemistry, Jnanabharathi Campus, Bangalore University, Bengaluru-560056, India.
Mohamed Afzal Pasha Department of Chemistry, Jnanabharathi Campus, Bangalore University, Bengaluru-560056, India.

10.22270/ujpr.v6i5.672

Keywords:

Araldehydes, 3,4-dihydropyrimidine-2-(1H)-ones/-thiones, ethyl acetoacetate, silica iodide, ultrasonication, urea/ thiourea

Abstract

Aim and objective: A single-pot three-component reaction for a competent preparation of biologically active 3,4-dihydropyrimidineones/-thiones using Silica Iodide (SiO₂-I) as a reliable and reusable heterogeneous catalyst is developed.

Methods: The reaction proceeds via condensation of araldehydes, urea/thiourea, ethyl acetoacetate in ethanol under ultrasonic condition to afford the target molecules in best yields. The reaction proceeds in 30 min and SiO₂-I has shown high proficiency in performing this single-pot Biginelli reaction.

Results: The use of catalytic SiO₂–I (0.1 g) accelerated the reaction and gave the product in excellent yield. Maximum yield of the product was found to be 96% in ethanol

Conclusion: Study concludes the used method has shown many advantages, mild condition, short duration, simple isolation and best yields of products.