DEVELOPMENT AND EVALUATION OF MICROEMULSION FORMULATIONS OF LORNOXICAM

Md. Shahidul Islam; Md. Irfan Uddin

doi:10.22270/ujpr.v7i6.867

Md. Shahidul Islam Department of pharmacy, University of Science and Technology Chittagong (USTC), Chattogram, Bangladesh.
Md. Irfan Uddin Department of pharmacy, University of Science and Technology Chittagong (USTC), Chattogram, Bangladesh.

10.22270/ujpr.v7i6.867

Keywords:

Co-surfactant, Lornoxicam, microemulsions, surfactant, thermodynamics

Abstract

Background and aims: Microemulsions (ME) basically are the mixture of oil, surfactant (SA) and water, with a co surfactant (Co-SA) in different ratio. This mixture is clear and stable. The final prepared fluid possesses low viscosity. ME are isotropic, stable transparent systems of with a droplets diameter>500 nm. Due to small droplets size, they may serve an excellent carrier for drugs having poor water solubility. Lornoxicam is derivative of allylamine, and is used orally in the treatment of hepatic failure, neutropenia.

Methods: In the present study an attempt was made to increase solubility of Lornoxicam by the means of ME formulations. Oil, surfactant and co-surfactant were selected based on their solubility criteria. Total 5 formulations were developed using water titration method. Prepared formulations were evaluated on different parameters.

Results: The percent transmission was found to be in the range of 98.48±0.15to 99.42±0.04. Refractive index for the micro emulsion formulations was found to be in the range of 1.3218±0.009 to 1.3720±0.021. Percent drug content was found to be in the range of 98.47±0.08 to 99.75±0.21. ME5 has shown faster drug release 91.2±0.06% in an in-vitro study of 4 hrs.

Conclusion: Study concluded that the means of microemulsions formulations solubility of Lornoxicam can be enhanced.