RECENT DEVELOPMENTS IN SYNTHETIC METHODS AND PHARMACOLOGICAL ACTIVITIES OF QUINAZOLINONE DERIVATIVES: A REVIEW

Omar N. Meftah; Ahshan Ali; Ali G. Al-kaf

doi:10.22270/ujpr.v9i6.1241

Omar N. Meftah Pharmaceutical Medicinal and Organic Chemistry, Faculty of Pharmacy, Sana’a University, Sana’a, Yemen.
Ahshan Ali Department of Pharmaceutical Sciences, Gurugram University, Gurugram Haryana, India.
Ali G. Al-kaf Pharmaceutical Medicinal and Organic Chemistry, Faculty of Pharmacy, Sana’a University, Sana’a, Yemen.

10.22270/ujpr.v9i6.1241

Keywords:

Anti-cancer, anti-inflammatory, anti-oxidant, anti-microbial, pharmacological activity, Quinazolinone, synthetic methods

Abstract

This review article offers A brief overview of the most current advancements in synthesis methods and with regard to the pharmacological effects of quinazolinone derivatives. A heterocyclic hybrid quinazolinone having the chemical formula C₈H₆N₂O. It is composed of rings that have been fused together i.e benzene and pyrimidine. The production of quinazolinone derivatives can be accomplished using a variety of methods, such as the Aza-diels-alder reaction, Aza-witting reaction, reaction aided by microwaves, metal-mediated synthesis, palladium-catalyzed reaction, copper-catalyzed reaction, ultrasound-promoted reaction, oxidative cyclization, reagent refluxing, one-pot synthesis, and aqueous media. This review paper included a wide spectrum of pharmacological activities, including a wide range of antibacterial, anti-inflammatory, and analgesic properties of quinazolinone derivatives as well as anti-cancer and anti-oxidant properties were covered in this study.