FORMULATION AND IN-VITRO  EVALUATION OF FLOATING MICROBALLOONS OF STAVUDINE

Felix Sunday Yusuf

doi:10.22270/ujpr.v1i1.R3

Felix Sunday Yusuf Contec Global Agro Limited, Abuja, Nigeria.

10.22270/ujpr.v1i1.R3

Keywords:

Stavudine, floating microballoons, floating drug delivery system, emulsion solvent diffusion method

Abstract

Objectives: Objective of present study involves preparation and evaluation of floating microballoons of Stavudine. It is a potent antiviral agent, used for treatment of human immunodeficiency virus (HIV) infection. In present study Stavudine is used as a model drug, to increase its residence time in the stomach without contact with the mucosa.

Methods: Eight floating microballoons formulations of Stavudine were prepared by using different polymers i.e. Eudragit S100, EC and PVP K30, in different ratio by emulsion solvent diffusion method. The microballoons were prepared by the emulsion solvent diffusion technique using different ratio of polymers (Eudragit S100, Ethyl cellulose and PVP K 30) as carriers.

Results: The mean particle diameter of the microballoons was between 230.23-238.33µm.The yield of microballoons was up to 68.32-80.22%. The cumulative percent drug release after 24 hrs of the Stavudine microballoons was in the range of 53.62 to 87.45%. The mean percentage buoyancy of the microballoons was between 69.23-82.53%. The cumulative percent drug release after 24 hrs of the Stavudine microballoons was 53.62 to 87.45%.

Conclusion: Stavudine floating microballoons formulations of batch MB4 was concluded as the optimum formulations among the all 8 formulations based on different parameters.Study concludes that stavudine can be delivered through floating microballoons dosage form in an effective way.