ABACAVIR LOADED NANOPARTICLES: PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN VITRO EVALUATION

Felix Sunday Yusuf; Yunus A A; Dingwoke Francis John; Udokwu Japheth Chigbo

doi:10.22270/ujpr.v1i2.R2

Felix Sunday Yusuf Department of Biochemistry, Ahmadu Bello University, P. M. B. 1045, Samaru, Zaria, Kaduna, Nigeria.
Yunus A A Department of Biochemistry, Ahmadu Bello University, P. M. B. 1045, Samaru, Zaria, Kaduna, Nigeria.
Dingwoke Francis John Department of Biochemistry, Ahmadu Bello University, P. M. B. 1045, Samaru, Zaria, Kaduna, Nigeria.
Udokwu Japheth Chigbo Department of Biochemistry, Ahmadu Bello University, P. M. B. 1045, Samaru, Zaria, Kaduna, Nigeria.

10.22270/ujpr.v1i2.R2

Keywords:

Abacavir, nanoparticles, solvent displacement method, zeta potential, entrapment efficiency

Abstract

Objectives: Abacavir is a nucleoside analog reverse transcriptase inhibitor (NRTI), antiretroviral drug; it is used in treatment of AIDS. The present study deals with the formulation and evaluation of Abacavir nanoparticles.

Methods: Abacavir nanoparticles were formulated by solvent displacement method using Eudragit RL-100, chitosan and Poloxamer-188. Nanoparticles were characterized by determining its particle size, drug entrapment efficiency, particle morphological character and in-vitro drug release.

Results: Particle size range of nanoparticles was in the range of 121.4-140.6 nm. Zeta potential of formulations was determined, and it was found in range of 16.5-20.45 mv. The in-vitro release of nanoparticles were carried out which exhibited a sustained release of Abacavir from nanoparticles up to 10 hrs.

Conclusion: The study concludes that nanoparticles can be a promising drug delivery system for sustained release of Abacavir in terms of increased bioavailability.