DEVELOPMENT AND EVALUATION OF NANOEMULSION FORMULATIONS FOR IMPROVED ORAL DELIVERY OF CARVEDILOL

Edenta Chidi; Ezeaku Ikenna N; Adamu Zainab; Dingwoke Francis John

doi:10.22270/ujpr.v2i1.R2

Edenta Chidi Department of biochemistry, Renaisance University, Enugu, Nigeria
Ezeaku Ikenna N Caribbean Medical University, Curaçao
Adamu Zainab Federal University of Technology Minna, Nigeria
Dingwoke Francis John Department of biochemistry, Ahmadu Bello University Teaching Hospital Zaria, Nigeria

10.22270/ujpr.v2i1.R2

Keywords:

Carvedilol, nanoemulsion, bioavailability, first-pass hepatic metabolism

Abstract

Objective: The aim of the present investigation was to develop, optimize and evaluate nanoemulsion system of carvedilol to improve its solubility, and oral bioavailability. Carvedilol is a non-selective beta blocker used in the treatment of mild to moderate congestive heart failure and mild to moderate essential hypertension. It has both poor water solubility (0.583 mg/L) and oral bioavailability (23%) because of significant first-pass hepatic metabolism.

Methods: Based on solubility testing, clove oil was used as oil, tween 20 was used as surfactants and PEG 400 was used as cosurfactants in construction of phase diagrams. Carvedilol nanoemulsions were prepared by aqueous phase titration method. Out of twelve formulations, eight thermodynamically stable formulations were selected for preparation of carvedilol loaded nanoemulsions and these nanoemulsions were subjected for characterization i.e. particle size, viscosity, polydispersity, zeta potential. A 12 hrs in-vitro release release study was performed on selected nanoemulsion formulations of carvedilol.

Results: The results of viscosity of carvedilol nanoemulsions were found to be in range (60.42 –134.63 m Pa.sec.). The results of pH measurement for formulations explain that the pH values of drug free nanoemulsions were slightly acidic. All formulations have PDI value less than (1.0).

Conclusion: Study concludes, nanoemulsion formulation of batch NEC4 (S_mix ratio 1:3) was found to be optimum formulation.