INNOVATIVE DRUG DELIVERY SYSTEMS FOR INFECTIOUS DISEASES OF THE SKIN

Abstract

Introduction: Skin is the organ of the body that is exposed mostly to the microorganisms. Bacteria, fungi, and viruses are usually responsible for the infection of the skin. Due to lack of penetration through the stratum corneum of conventional systems used in infectious diseases of the skin leads to a decrease in bioavailability. For this reason, nanoscale drug delivery systems that could be used in infectious diseases of the skin are currently being investigated.

Areas covered: In this review, innovative studies conducted over the years are presented. New topical formulations such as nanoparticles, microemulsions, liposomes, nanofibers and micelles etc are widely used and topic of research for many researchers.

Conclusion:  Studies have shown that the smaller size and control of these delivery systems provide more effective treatment by increasing drug penetration into the skin. It has been found that drug delivery systems provide a better antimicrobial effect, especially in resistant infections caused by MRSA.

Keywords: drug delivery systems, modified release dosage forms, skin infectious diseases, topical.

                      

Peer Review History:

Received: 1 June 2022; Revised: 9 July; Accepted: 18 August; Available online: 15 September 2022

Academic Editor: Dr. Rola Jadallah, Arab American University, Palestine, rola@aauj.edu

Received file:                             Reviewer's Comments:

Average Peer review marks at initial stage: 5.0/10

Average Peer review marks at publication stage: 7.0/10

Reviewers:

Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye

Dr. Nuray Arı, Ankara University, Turkiye, ari@ankara.edu.tr