REVIEW ON CELLULAR SIGNALING, GROWTH FACTORS, AND MECHANICAL STIMULUS IN NERVE REGENERATION

Ezegbe Chekwube Andrew; Amarachi Grace Ezegbe

doi:10.22270/ujpr.v9i6.1246

Ezegbe Chekwube Andrew Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka, Nigeria. Nanoscience and Advanced Materials, Graduate Program (PPG-Nano), Federal University of ABC, Avenida dos Estados, Santo Andre, Sao Paulo, Brazil.
Amarachi Grace Ezegbe Department of Home Science and Management, University of Nigeria, Nsukka, Nigeria.

10.22270/ujpr.v9i6.1246

Keywords:

Axons, growth factors, peripheral nerve injury, signaling cascade

Abstract

The nervous system consists of the autonomous and peripheral. Injury on the peripheral nerve which occurs due to trauma, accident and other associated factors always results in a huge loss of both the motor and sensory functions. The injured nerves can be successfully restored although it requires a lot of molecular response in order to rebuild the functional axons. When this is achieved, the damaged nerve can accurately connect with their original targets. The complete recovery of PNI has not been optimized. Exogenous growth factors (GFs) are a new therapeutic strategy that can be used in nerve regeneration. The mechanism of action of growth factor is based on the ability to activate the signaling cascades via binding to the individual receptors in order to exert the multiple effects and restore the neuron and tissue regeneration. Although the GFs are limited by their short half-life and rapid deactivation. The use of nerve conduits has been able to reduce these limitations. The nerve conduits have been good biocompatibility and biofunctionality properties.