REVIEW ON CELLULAR SIGNALING, GROWTH FACTORS, AND MECHANICAL STIMULUS IN NERVE REGENERATION

Ezegbe Chekwube Andrew; Amarachi Grace Ezegbe

doi:10.22270/ujpr.v9i6.1246

Ezegbe Chekwube Andrew Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka, Nigeria. Nanoscience and Advanced Materials, Graduate Program (PPG-Nano), Federal University of ABC, Avenida dos Estados, Santo Andre, Sao Paulo, Brazil.
Amarachi Grace Ezegbe Department of Home Science and Management, University of Nigeria, Nsukka, Nigeria.

10.22270/ujpr.v9i6.1246

Keywords:

Axons, growth factors, peripheral nerve injury, signaling cascade

Abstract

The autonomous and peripheral constitute the entire nervous system. Peripheral nerve injury caused by trauma, accident and other associated factors always results in a huge loss of both the sensory and motor functions. The injured nerves can be successfully restored through the rebuilding of the functional axons. The complete recovery of PNI has not been optimized. Exogenous growth factor (GF) is a new therapeutic strategy that can be used in nerve regeneration. Growth factors mechanism of action is based on the ability to activate the signaling cascades via binding to the individual receptors in order to exert the multiple effects and restore the neuron and tissue regeneration. Although the GFs are limited by their short half-life and rapid deactivation. The use of nerve conduits has been able to reduce these limitations. The nerve conduits have been good biocompatibility and biofunctionality properties.