DEVELOPMENT AND CHARACTERIZATION OF DIRECT COMPRESSED MATRIX MINI TABLETS OF NAPROXEN SODIUM

Abstract

Objective:  The present study was carried out to formulate and evaluate multiparticulate system containing mini-tablets of Naproxen sodium. Naproxen is a nonsteroidal anti-inflammatory drug (NSAIDs) with analgesic and antipyretic properties.

Methods: Pre-formulation studies showed good flow and compaction capacity, leading to the production of high quality mini-tablets. The drug-excipients compatibility studies were performed using FTIR techniques. Ten different matrix mini tablets were manufactured by direct compression using various polymers like HPMC K4M, PVP K30 in different ratio. The prepared mini tablets were subjected to pre and post compressional parameters and the values were within the prescribed limits.

Results: The in-vitro performance showed the desired biphasic behaviour. Drug release from matrix mini tablets was sustained over a period of 10 hours and release rate.

Conclusion: Study concludes that Naproxen sodium can be successfully released in a controlled manner by the use of developed matrix mini-tablets.

Peer Review History:

Received 5 August 2018; Revised 19 September; Accepted 29 October, Available online 15 November 2018

Academic Editor: Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt, gehankandeel9@yahoo.com 

Received file:        Reviewer's Comments:

Average Peer review marks at initial stage: 4.0/10

Average Peer review marks at publication stage: 7.0/10

Reviewer(s) detail:

Dr. Branislav Ranković, University of Kragujevac, Serbia, rankovic@kg.ac.rs

Prof. Dr. Kapil Kumar, Global Institute of Pharmaceutical Education and Research,
Kashipur, US Nagar, Uttarakhand, India, kapil5november@gmail.com