IN VITRO DISSOLUTION STUDY OF GLIMEPIRIDE FROM BINARY AND TERNARY SOLID DISPERSION FORMULATION

Abstract

Objective: Glimepiride (GMP) is poorly water soluble drug, so solubility is the main constraint for its oral bioavailability. Because, poor aqueous solubility and slow dissolution rate of the glimepiride lead to irreproducible clinical response or therapeutic failure in some cases due to sub therapeutic plasma drug levels.

Methods: In this study, binary and ternary solid dispersion of glimepiride were prepared with polyethylene glycol 6000 (PEG 6000) and polyethylene glycol 4000 (PEG 4000) at different weight ratios using the solvent evaporation and melting method.

Results: It was found the drug was released 0.46% after 5 minutes and only 15.83% within 60 minutes from active glimepiride on the other hand the release pattern of glimepiride from the binary formulation containing PEG 4000 in 1:5 (Formulation coding: G5) showed the best result.

Conclusion: It was found that the ternary different SD formulation containing (PEG4000: Glimepiride: Povidone) in ratio 1:1:0.25 (Formulation G13) showed the best result. The drug was changed to amorphous form after solid dispersion. It was also evident that solid dispersions improve solubility of drug particles thus enhancing dissolution characteristics of drugs they increase the oral bioavailability.

                               

Peer Review History:

Received 1 August 2019;   Revised 6 September; Accepted 28 October, Available online 15 November 2019

Academic Editor: Rola Jadallah, Arab American University, Palestine, rola@aauj.edu

Received file:                Reviewer's Comments:

Average Peer review marks at initial stage: 4.5/10

Average Peer review marks at publication stage: 7.5/10

Reviewer(s) detail:

Dr. Mohammed Abdel-Wahab Sayed Abourehab, Umm Al-Qura University; Makkah Al-Mukarramah, Saudi Arabia, mohawahab2002@yahoo.com

Dr. Evren Alğin Yapar, Turkish Medicines and Medical Devices Agency, Turkiye, evren.yapar@yahoo.com