A NOVEL QUATERNARY ALKALOID N-METHYLCORYXIMINE FROM HYPECOUM PENDULUM L.

Abstract

Objective: In this study, the isolation and chemical structure elucidation of a new alkaloid from Hypecoum pendulum L is provided.

Material and Methods: Column and ascending preparative thin layer chromatographic methods were utilized for the purification of the novel compound. The structure elucidation was determined based on spectroscopic methods including infrared (IR), nuclear magnetic resonance (NMR), and Mass (MS) spectroscopy.

Results: N-methylcoryximine, a quaternary alkaloid from secoberbine subgroup of isoquinoline alkaloids, was isolated and the structure of this compound was elucidated.

Conclusion: The natural occurrence and spectral data of N-methylcoryximine is reported for the first time.

                          

Peer Review History:

Received: 9 February 2022; Revised: 12 March; Accepted: 14 April; Available online: 15 May 2022

Academic Editor: Dr. Emmanuel O. Olorunsola, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria, olorunsolaeo@yahoo.com

Received file:                             Reviewer's Comments:

Average Peer review marks at initial stage: 5.5/10

Average Peer review marks at publication stage: 7.0/10

Reviewers:

Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt, gehankandeel9@yahoo.com 

Dr. Nazim Hussain, North East Frontier Technical University, Arunachal pradesh, India, nhussain116@gmail.com