BUCCAL DRUG DELIVERY SYSTEM: A TOOL FOR THE EFFECTIVE DELIVERY OF PHARMACEUTICALS

Abstract

The Buccal drug delivery system includes drug administration through the buccal mucosa, mainly composed of the lining of the cheeks. Buccal drug delivery system provides a convenient route of administration for both systemic and local drug actions. Buccal films can improve the therapeutic effect of drug by increasing the absorption of drug through oral mucosa which increases the drug bioavailability by reducing the hepatic first pass effect. In recent years, many researchers are working on the delivery of drugs through the oral mucosa which have a high first pass metabolism or degrade in the gastrointestinal tract. Furthermore, buccal drug delivery has a high patient acceptability compared to other non-oral transmucosal routes of drug administration. It provide direct access to the systemic circulation through the internal jugular vein thus avoids acid hydrolysis in the gastrointestinal tract and bypasses drugs from the hepatic first pass metabolism leading to high bioavailability. This article deals with the development and evaluation parameters used at present and future role of the system for the treatment of diseases by incorporating different class of drugs.

Peer Review History:

Received 9 April 2017;   Revised 11 May; Accepted 25 June, Available online 15 July 2017

Academic Editor: Dr. Amany Mohamed Alboghdadly, Princess Nourah bint abdulrahman university, Riyadh, amalbgadley@pnu.edu.sa

Received file:        Reviewer's Comments:

Average Peer review marks at initial stage: 4.5/10

Average Peer review marks at publication stage: 7.0/10

Reviewer(s) detail:

Razan Haddad, Jordan University of Science and Technology, Jordan, razanhh@yahoo.com

Dr. Amany Mohamed Alboghdadly, Princess Nourah bint abdulrahman university, Riyadh, amalbgadley@pnu.edu.sa