FAST DISSOLVING TABLETS: A PROMISING APPROACH FOR DRUG DELIVERY

Abstract

Aim of novel drug delivery system is to enhance safety and efficacy of drug molecules by formulating a convenient dosage form for administration and to achieve better patient compliance. One such approach led to development of fast dissolving tablets. Now-a-days fast disintegrating tablets (FDTs) gaining significance with wide variety of drugs serving many purposes. These are novel types of tablets that disintegrate/dissolve/ disperse in saliva within few seconds (less than 60 seconds) without chewing and additional water. The basic approach used in development of FDTs is the use of superdisintegrants and the elimination of bitterness. FDTs reduces the disadvantages of conventional dosage form especially dysphasia (difficulty in swallowing) in pediatric and geriatric patients. These oral dosage forms have many benefits such as self medication, increased compliance, ease of manufacturing and noninvasive. This review presents description of fast dissolving tablets including need for development, challenges in formulation, suitability of drug candidates, composition, various technologies involved, advantages, disadvantages, and evaluation parameters.

                                        

Peer Review History:

Received 27 May 2017;   Revised 3 July; Accepted 27 August; Available online 15 September 2017

Academic Editor: 

Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com

Received file:        Reviewer's Comments:

Average Peer review marks at initial stage: 4.0/10

Average Peer review marks at publication stage: 7.0/10

Reviewer(s) detail:

Dr. Ogbonna B. Onyebuchi, Nnamdi Azikiwe University, Awka,  Nigeria, summitpharm@yahoo.com

Dr. Gülay B Anadolu, Anadolu University, Eskisehir, Turkey, gbuyukko@anadolu.edu.tr